CBA using live cells transfected with full-length human MOG and employing Fc-specific detection antibodies are the gold standard for anti-MOG antibody testing. MOG-IgG is detected by means of so-called cell-based assays (CBA). Finally, in MOGAD, infiltrating lymphocytes are mainly CD4+ T-cells with low numbers of CD8+ T-cells and B-cells the dominant lymphocytes in active MS lesions are tissue resident CD8+ effector memory T-cells and B-cells / plasma cells.While in MS the dominant inflammatory reaction is seen around the larger drainage veins in the periventricular tissue and the meninges, in MOGAD the smaller veins and venules are mainly affected. Demyelination in MOGAD is associated with complement deposition at the site of active myelin injury, but the degree of complement activation is much less compared to that seen in patients with aquaporin 4 antibody associated neuromyelitis optica (NMO). MOGAD demyelination occurs by confluence of small perivenous lesions, generally resulting in a demyelination pattern similar to that seen in acute disseminated encephalomyelitis.Several studies performed during 2020 have shown that MOGAD lesions differ from those seen in MS in many aspects, including their topographical distribution in the CNS, the type of demyelination, and the nature of the inflammatory response. They are similar to pattern-II multiple sclerosis with T-cells and macrophages surrounding blood vessels, preservation of oligodendrocytes and signs of complement system activation. Histopathology ĭemyelinating lesions of MOG-associated encephalomyelitis resemble more those observed in multiple sclerosis than NMO. Other reports point to molecular mimicry between MOG and some viruses as a possible etiology. The reason why anti-MOG auto-antibodies appear remains unknown.Ī post-infectious autoimmune process has been proposed as a possible pathophysiologic mechanism. Rare cases of anti-MOG antibodies in association with tumefactive multiple sclerosis have been described. The presence of anti-MOG antibodies is more common in children with ADEM. However, the coexistence of both antibodies is still a matter of ongoing debate. These patients typically have MS-like brain lesions, multifocal spine lesions and optic nerve atrophy. Rare cases have been described of patients with antibodies against both AQP4 and MOG. However, most NMOSD is an astrocytopathy, specifically an AQP4 antibody-associated disease, whereas MOG antibody-associated disease is an oligodendrocytopathy, suggesting that these are two separate pathologic entities. Seronegative neuromyelitis optica Īnti-MOG antibodies have been described in some patients with NMOSD who were negative for the aquaporin 4 (AQP-4) antibody. Some of these phenotypes have been studied in detail: The most common presenting phenotypes are acute disseminated encephalomyelitis (ADEM) in children and optic neuritis (ON) in adults. Aseptic meningitis and meningoencephalitis (typically post-infectious).Optic neuritis (including cases of CRION ( chronic relapsing inflammatory optic neuropathy ).Acute disseminated encephalomyelitis, especially in recurrent and fulminant cases.The presence of anti-MOG autoantibodies has been described in association with the following conditions: The clinical presentation is variable and largely dependent upon the overall clinical manifestation. Serum anti-myelin oligodendrocyte glycoprotein antibodies are present in up to half of patients with an acquired demyelinating syndrome and have been described in association with a range of phenotypic presentations, including acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, and neuromyelitis optica. MOG antibody disease (MOGAD) or MOG antibody-associated encephalomyelitis (MOG-EM) is an inflammatory demyelinating disease of the central nervous system.
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Move the focus to the first floating shape, such as an image or a text box. Paste copied formatting to the selected object or text. Office 2010 and Office 2007: Not availableĬopy the formatting of the selected object or text. Top of Page Work with objects and text Copy objects and text Save a presentation with a different name, location, or file format. Top of Page Work with presentations and slides Paste cut or copied text, object, or slide. The following table itemizes the most frequently used shortcuts in PowerPoint.Īpply bold formatting to the selected text. Get the PowerPoint 2016 keyboard shortcuts in a Word document at this link: PowerPoint 2016 for Windows keyboard shortcuts. For instructions, refer to Use a keyboard to customize the Quick Access Toolbar. If an action that you use often does not have a shortcut key, you can add it to the Quick Access Toolbar to create one. Press Ctrl+F and then type your search words. Before you send files to clients or coworkers, you may also want to break the links.To quickly find a shortcut in this article, you can use the Search. If you choose to link to Excel files in PowerPoint, you'll often need to manage the links. Navigate to the new location of the file and click on it. If the source file has been moved or renamed, you will need to change the source. You can also select the Automatic Update checkbox to automatically update when the file is opened.
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So, you don’t need to worry.Īlternatively, the dream meaning of snakes may symbolize good luck since you fight with hostile people, in some way life shows you beauties. A snake egg denotes that there is someone who has hostile feeling about you but he or she won’t be able to hurt you. A baby snake signifies that you are ignoring dangers in your life. If you dream a small snake, then it suggests that your enemy is weaker than you. If you see a big snake, that means your enemy is stronger than you. Moreover, you aren’t aware of this person’s feelings about you. In other words there may be someone who wants you not to be successful or happy. To see that the snake lays eggs in the house in your dream means that you deal with the public work.ĭream with snakes is usually a sign of an your hostiles. To see a lot of snakes in a place in your dream indicates that you will get rid of your fears and deal with spiritual works. If you are single, it refers to sister/brother or a baby of another person. To see of eating snake meat in your dream implies that you will have a baby. If you aren’t afraid of the snake, it signifies a person who keeps you out of harm’s way. To see that you are afraid of the snake in your dream means that you will meet with a person who doesn’t bring good things. If you are bitten by a white snake in your dream, it refers to money which you will earn. To dream that you are bitten by a black snake indicates that you will hear good news. So, claws or horn is symbol of hatred and evil. This means he or she will be more dangerous for you. A snake with claws and horn in your dream suggests that your enemy is getting more powerful and stronger. Your enemy has a high level position in business life and is stronger than you. To see a snake which has many feet usually implies you have an enemy who is respected by other people. To see that the snake has feet in your dream means that you will have property as much as the high of the snake. To see that you are speaking with the snake in your dream may suggest that you will make peace with your enemy. If you touch on the snake without being scared and cut it, it also means that you will have the superiority over your enemy. To dream that you kill a snake means that you will have the superiority over your enemy. The size of the snake refers to the amount of the property of the enemy. If you see the snake outside, it indicates that there is an enemy outside. To see a snake in a dream refers to a deceitful enemy. To see that the snake is at your home in your dream means that there is an enemy in your house. Besides, the type of snake differs the dream meaning. The dream interpretation of snakes depends on what you see in your dream. "Z" Letter Dream Interpretation Dictionary (3)."Y" Letter Dream Interpretation Dictionary (5)."W" Letter Dream Interpretation Dictionary (71)."V" Letter Dream Interpretation Dictionary (26)."U" Letter Dream Interpretation Dictionary (11)."T" Letter Dream Interpretation Dictionary (103)."S" Letter Dream Interpretation Dictionary (139)."R" Letter Dream Interpretation Dictionary (44)."Q" Letter Dream Interpretation Dictionary (10)."P" Letter Dream Interpretation Dictionary (85)."O" Letter Dream Interpretation Dictionary (20)."N" Letter Dream Interpretation Dictionary (23)."M" Letter Dream Interpretation Dictionary (45)."L" Letter Dream Interpretation Dictionary (59)."K" Letter Dream Interpretation Dictionary (12)."J" Letter Dream Interpretation Dictionary (15)."I" Letter Dream Interpretation Dictionary (12)."H" Letter Dream Interpretation Dictionary (31)."G" Letter Dream Interpretation Dictionary (49)."F" Letter Dream Interpretation Dictionary (50)."E" Letter Dream Interpretation Dictionary (54). "D" Letter Dream Interpretation Dictionary (83)."C" Letter Dream Interpretation Dictionary (145)."B" Letter Dream Interpretation Dictionary (150)."A" Letter Dream Interpretation Dictionary (121). With the help of lucky star Yue De, your career development will be smooth sailing. Dragons, your fortunes will be affected by some opposition to Tai Sui (the Age Star), but there is no need to worry too much, because you will also be taken care of by lucky stars this year. Unlucky months: the 5th and 6th Chinese lunar monthsĢ023 is a year of the Rabbit.Lucky months: the 3rd, 4th, and 7th Chinese lunar months.Lucky flowers: bleeding-heart glory bower, dragon flowers.Lucky colors: gold, silver, grayish white.Lucky days: the 1st and 16th of any Chinese lunar calendar month.In Chinese element theory, each zodiac sign is associated with one of five elements: Gold (Metal), Wood, Water, Fire, or Earth, which means that a Wood Dragon, for example, comes once in a 60-year cycle. Instead of following tradition, they strive for a smooth future. They don't consider themselves irritating and arrogant. However, Dragons are sometimes regarded as aggressive, and angry Dragons are not open to criticism. They are not afraid of challenges, and willing to take risks. Gifted with innate courage, tenacity, and intelligence, Dragons are enthusiastic and confident. In ancient times, people thought that Dragons were best suited to be leaders of the world with their character traits of dominance and ambition. The Chinese dragon is the most vital and powerful beast in the Chinese zodiac, although Dragons have an infamous reputation for being a hothead and possessing a sharp tongue. The Dragon's Personality: Confident, Intelligent.Īmong the Chinese zodiac animals, the dragon is the sole imaginary animal. If you do not use Apple iPhone/iPad/iPod, you need to convert AIFF to MP3 to fix the incompatible issue. By the way, MP3 is the worldwide popular audio formats that are supported by almost all audio players. Of course, some not important portions of audio information will be discarded. Generally speaking, you can get pretty good audio quality with lossy MP3 audio format. Because AIFF consumes about 10MB for per minute of audio at 44.1kHz.Īs for compressed MP3 audio format, you can get about 1MB for every minute of audio recording. Well, you can regard it as the major drawback of AIFF too. Thus, AIFF format is widely used by professional level audio applications. AIFF (Audio Interchange File Format) is the audio format developed by Apple with a long history. The main difference between AIFF and MP3 is compression. To start with, let's figure out the battle of AIFF VS MP3. Part 1: AIFF VS MP3, What Is the Best Format for Music Part 3: How to Convert AIFF to MP3 with Audacity.Part 2: Best Way to Convert AIFF to MP3 Online for Free.Part 1: AIFF VS MP3, What Is the Best Format for Music.Just read and follow steps below to convert AIFF to MP3 for free online or offline. Thus, you can convert large AIFF files to MP3 in bulk quickly and easily. This article will show you two awesome AIFF to MP3 converters for batch audio conversion. There are many online and offline AIFF to MP3 audio converters in the market. "I'm looking for a tool for AIFF to MP3 mass converting…"īy converting AIFF to MP3, you can get the same content with the pretty good audio quality and a small file size. Hey guys, what's the best converter for AIFF to MP3 that I can get for free?" 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Seriously? …….Let’s start by first clearing up some confusion, I am not saying that this is the best camera ever, but definitely one of the best camera packages ever when factoring in everything like price, size, weight, versatility, video, etc. I decided to simplify and only get one camera that would work for most situations and the LX100 seemed to fit the bill well. I was leaving for Korea and could not take all of my cameras with me. I got the LX100 because in a sense, I needed to. Fast zooms are great, the LX100 grew on me. $300-plus: 30x optical zoom touchscreen and/or swiveling LCD very good performance in low light manual settings burst mode of 10 frames per second top ISO of 12,800 ISO.īe sure to check out all of our camera picks:īest cameras | Best DSLR cameras | Best action cameras | Best waterproof cameras | Best instant cameras | Best mirrorless cameras | Best cheap cameras | Best GoPro camera | Best GoPro accessories | Best drones | Best 360 cameras | Best iPhone lenses | Best iPhone tripods | DSLR vs.Second I used to be anti-zoom, I used to be a passionate defender of prime lenses, but with that zoom range basically removing the need to carry another lens, I’m not too zealous about my position as a prime shooter anymore.$250: 25x optical zoom RAW still-photos.$200: 12x optical zoom stylish camera-body designs 1080p full HD video 3200 ISO burst mode at 7 frames-per-second.$160: 10x optical zoom built-in Wi-Fi and NFC connectivity optical image stabilization improved low-light performance.$120: 8x optical zoom 24mm wide-angle lens smart auto mode (automatically determines the proper mode for the scene) digital or electronic image stabilization larger selection of scene modes includes help features or in-camera tips.$75: 3x-5x optical zoom 2.7-inch LCD 28mm wide-angle lens small selection of scene modes, such as panorama, beach, and sunset modes.$50 or less: No optical zoom (fixed-focal length) 4x digital zoom built-in flash 1.8-inch LCD runs on AA or AAA batteries 720p HD video.Note that almost all point-and-shoots at this time have between 16 and 20 megapixel sensors: Use the following list as a guide of what features you’ll begin to see at particular price points. In fact, a point-and-shoot that costs more than $300 will most likely be classified as a bridge camera or a rugged-and-waterproof camera. Not surprisingly, the better features - such as longer optical-zoom lenses or in-camera image stabilization - are found in the pricier models, but competition is still keeping prices lower than in years past. But with so many changes taking place in the camera market, what features are you getting in the models that are available? While many consumers choose to shoot most of their photos and videos on smartphones, some still like the convenience and quality you can get with a stand-alone point-and-shoot digital camera. How to choose the best point-and-shoot camera for you Read our full Panasonic Lumix ZS200 review. Low-light shots were good, and also did great when shooting 4K video. It's easy enough for beginners, but has an array of dials and controls for advanced amateurs to take command of all of the camera's settings.Īlthough its rear display doesn't tilt, we also liked its sharp electronic viewfinder. With a 15X zoom (24-360mm equivalent), the Panasonic Lumix ZS200 is the best compact camera for travelers who are looking for a small yet versatile shooter. Use other veggies like bell pepper, or swap cilantro for spinach. You’ll need a rolling pin and something to cut the dumplings with. Stir in the milk, mixing with a fork until the dough forms a ball. Cut the butter into the dry ingredients with a fork or pastry blender. Use cooked chicken breasts or rotisserie chicken. In a bowl, combine the flour, baking powder and salt. This keeps the end product from being too greasy. Spread the prepared peanut butter sauce, pile shredded chicken, carrots, cucumber and cilantro onto a tortilla to make these quick and easy wraps. 14 oz can diced tomatoes 1/2 tsp ground cumin 3 cloves garlic minced 1-2 chipotles in adobo sauce 1 small onion roughly chopped 2/3 cup diced or shredded. Step 1 Boil chicken quarters in a large pot after removing most of the skin. Full of vegetables, ideal for a midweek meal. Use cooked chicken or leftovers from a roast chicken for these peanut chicken wraps, which need just 15 minutes to prep. Start rolling, fold the opposite sides in toward the center, then roll the wrap up. Warm the flour tortillas a few seconds in the microwave for an easy roll-up and top with your desired filling. We start by arranging the ingredients in an assembly line for easy access. Meanwhile, combine flour, baking soda, and remaining. Rolling a tortilla wrap is surprisingly easy. Directions Place chicken, celery, and carrots in a Dutch oven add water and 2 teaspoons of the salt. The homemade classic takes a bit of work but is certainly worth it. Also perfect for picnics, parties or brunches. 1 / 25 Slow-Cooker Chicken & Dumplings Here’s a homey dish that people just can’t wait to dive into Yes, you can have slow cooker chicken and dumplings. These wraps are perfect for a speedy midweek meal or a super delicious treat to add to your lunchbox. There’s something for everyone, spicy peanut chicken with crunchy cucmber, buttery avocado with mozzarella and pesto, and how about mashed feta with sun dried tomato pesto and smashed chickpeas. 51 Comments Old-fashioned southern style chicken and dumplings. Remove from heat and finish off with the chopped fresh parsley.Ĭalories 350, Total Fat 14g, Carbohydrates 25g, Fiber 3g, Protein 33g, Sodium 480mg, Cholesterol 80mg SOURCE (OR ADAPTED FROM)įood.com/recipe/weight-watchers-chicken-dumplings-made-with-tortillas-350800 and /od/ingredientsubstitutions/r/bl90911a4.3 easy tortilla wrap recipes to spice up your lunch routine.Stir in the frozen carrots, chicken, onion powder, garlic, salt, and pepper. Whisk in the cream of chicken soup and the cream of celery soup. In a small skillet, pour the olive oil and place the grated carrot and onion. Place the chicken broth into a dutch oven or large heavy bottom pot. Cook the chicken for about 20 minutes and remove the foam from the broth. Put the pot over medium heat and let it boil. Lower heat to medium low and let simmer for 10 minutes. Place the chicken breast and the bay leaf in a medium stock pot and fill it with water. Add cream soup to chicken and continue to. The extra flour on them will help thicken the broth. Prepare dumplings and set them aside for a few minutes. Drop the dumplings in one at a time, stirring while you add them. In a mixing bowl, whisk together 1/2 cup (62.5g) all-purpose flour and a few ladles of soup until the flour fully dissolves. Stir and break some of the potatoes to thicken soup. Add in 1/2 - 1 cup (60 - 120g) frozen green peas. Remove skin and bones at this point, along with bay leaves. Thicken Chicken and Dumplings: Bring the soup to a simmer.
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